Less than two months before his death from colorectal cancer at 48, James Van Der Beek shared a message that now feels especially urgent: “You can have no symptoms and still have cancer.” It was simple, but powerful.

Colorectal cancer remains one of the deadliest cancers worldwide. In 2020, an estimated 930,000 people died globally. In the United States, projections for 2026 suggest about 55,230 deaths, making it the second-leading cause of cancer-related deaths among men and women combined, according to the American Cancer Society.

Van Der Beek revealed in a 2024 interview with People that he had been diagnosed with stage 3 colorectal cancer at 46. He said he had associated cancer with older age or unhealthy lifestyles, not with someone in strong physical condition like himself.

His diagnosis followed subtle symptoms in 2023, including changes in bowel habits that he initially dismissed. When adjustments to his diet didn’t help, he chose to get checked.

A colonoscopy confirmed the cancer. He later recalled going into shock after hearing the news, especially since he had felt relatively well beforehand.

Colorectal cancer can be difficult to detect early. Warning signs may include abdominal discomfort, fatigue, unexplained weight loss, rectal bleeding, or ongoing changes in bowel habits—but some people experience no noticeable symptoms at all.

Screening is widely recommended beginning at age 45 in many regions. Early detection significantly improves outcomes, often allowing treatment through surgery and, if necessary, chemotherapy or radiation.

In his final months, Van Der Beek emphasized awareness over sympathy. He encouraged others not to wait for serious symptoms before seeking screening. His message remains clear: early testing can save lives.